Peptidyl ketones as inhibitors of dpiv

Details Peptidyl ketones as inhibitors of dpiv Peptidyl ketones as inhibitors of dpiv

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/04 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61P 3/10 (2006.01) A61P 25/00 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2461170

The present invention relates to compounds of the general formula (I), and pharmaceutically acceptable salts thereof, to the use of the compounds for the treatment of impaired glucose tolerance, glucosuria, hyperlipidaemia, metabolic acidosis, diabetes mellitus, diabetic neuropathy and nephropathy and of sequelae caused by diabetes mellitus in mammals.

Cette invention, qui a trait à des composés correspondant à la formule générale (I), ainsi qu'à leurs sels acceptables du point de vue pharmaceutique, concerne également l'utilisation qui en est faite pour traiter l'intolérance au glucose, la glycosurie, l'hyperlipidémie, l'acidose métabolique, le diabète sucré, la neuropathie et la néphropathie diabétiques ainsi que les séquelles causées par le diabète sucré chez les mammifères.

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