Biomarker for sensitivity to mtor inhibitor therapy in...

Details Biomarker for sensitivity to mtor inhibitor therapy in... Biomarker for sensitivity to mtor inhibitor therapy in...

G - Physics

01

N

G01N 33/50 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2604983

The invention disclosed herein provides methods for the examination and/ or quantification of biochemical pathways that are disregukted in pathologies such as cancer and to reagents and kits adapted for performing such methods. For example a correlation between VHL loss and mTOR inhibitor sensitivity in human kidney cancer cells is disclosed, indicating that VHL loss confers autonomous and angiogenic competitive advantages to such cells.

La présente invention concerne un procédé destiné à l'examen et/ou la quantification des voies biochimiques qui sont régulées dans des pathologies telles que le cancer du rein. L'invention concerne également des réactifs et des nécessaires conçus pour la mise en oeuvre de ce procédé. Par exemple, on fait état d'une corrélation entre la perte du gène suppresseur de la tumeur VHL (Von Hippel-Lindau) et la sensibilité à l'inhibiteur du mTOR dans les cellules cancéreuses du rein humain, ce qui voudrait dire que cette perte confère à de telles cellules un avantage compétitif d'autonomie et d'angiogénicité.

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