Process for preparing purine derivatives

Details Process for preparing purine derivatives Process for preparing purine derivatives

C - Chemistry, Metallurgy

07

D

C07D 473/18 (2006.01) C07D 473/00 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2243650

Process and novel intermediates for preparing the L-monovaline ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol (see above formula) and its pharmaceutically acceptable salts. The present process and intermediates provide for reduced impurities in the monovaline ester end-product, also eliminating the costly and time consuming purification step and allowing the use of starting materials of lower purity, which, in turn, reduces overall production costs. The products are of value as antiviral agents with improved absorption.

L'invention concerne un procédé et de nouveaux intermédiaires pour préparer l'ester L-monovaline de 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)méthoxy-1,3-propanediol et ses sels pharmaceutiquement acceptables. Le présent procédé et les intermédiaires permettent de réduire les impuretés dans le produit final d'ester mono-valine, et suppriment l'étape de purification onéreuse et longue. Par ailleurs, ils permettent d'utiliser des produits de départ d'une pureté inférieure ce qui réduit les coûts de production globaux. Ces produits sont très utiles comme agents antiviraux et présentent une absorption améliorée.

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