C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 19/00 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 213/30 (2006.01) C07D 213/74 (2006.01) C07D 233/70 (2006.01) C07D 233/74 (2006.01)
Patent
CA 2710943
The invention relates to compounds of the formula (I) in which: X is a substituted phenyl group; R1 is a hydrogen atom, a halogen, a (C1-C6) alkoxy group, a (C1-C6) alkyl group, an NRaRb group; R2 is a hydrogen atom, an optionally substituted (C1-C6) alkyl group, an optionally substituted (C1-C6) alkoxy group, a (C2-C6) alkenyl group, a (C2-C6) alkynyl group, a -CO-R5 group, a -CO-NR6R7 group, a -CO-O-R8 group, a - NR9-CO-R10 group, a -NR11R12 group, a N=CH-NRaRb group, a halogen atom, a cyano, nitro, hydroxyiminoalkyl, alkoxyiminoalkyl group, a (C1-C6) alkylthio group, a (C1-C6) alkylsulphinyl group, a (C1-C6) alkylsulphonyl group, a (((C1- C6)alkyl)3)silylethynyl group, a -SO2-NR9R10 group, a phenyl group optionally substituted by one or more groups selected independently from each other from the following atoms or groups: halogen, (C1-C6) alkoxy, cyano, NRaRb, -CO-R5, -CO- NR6R7, -CO-O-R8, a (C1-C6) alkyl group optionally substituted by one or more hydroxy or NRaRb; R3 is a hydrogen atom, a (C1-C6) alkyl group, a (C1-C6) alkoxy group or a halogen atom; R4 is a hydrogen atom, a (C1-C4) alkyl group, a (C1-C4) alkoxy group or a fluorine atom; said compounds being in the state of a base or an addition salt to an acid. The invention can be used in therapeutics.
The invention relates to compounds of the formula (I) in which: X is a substituted phenyl group; R1 is a hydrogen atom, a halogen, a(C1-C6) alkoxy group, a(C1-C6) alkyl group, an NRaRb group; R2 is a hydrogen atom, an optionally substituted (C1-C6) alkyl group, an optionally substituted (C1-C6) alkoxy group, a(C2-C6) alkenyl group, a(C2-C6) alkynyl group, a-CO-R5 group, a-CO-NR6R7 group, a-CO-O-R5 group, a - NR9-CO-Rio group, a-NR11R12 group, a N=CH-NRaRb group, a halogen atom, a cyano, nitro, hydroxyiminoalkyl, alkoxyiminoalkyl group, a(C1-C6) alkylthio group, a(C1-C6) alkylsulphinyl group, a(C1-C6) alkylsulphonyl group, a(((Ci- C6)alkyl)3)silylethynyl group, a-SO2-NR9R10 group, a phenyl group optionally substituted by one or more groups selected independently from each other from the following atoms or groups: halogen, (C1-C6) alkoxy, cyano, NRaRb, -CO-R5, -CO- NR6R7, -CO-O-R5, a(C1-C6) alkyl group optionally substituted by one or more hydroxy or NRaRb; R3 is a hydrogen atom, a(C1-C6) alkyl group, a(C1-C6) alkoxy group or a halogen atom; R4 is a hydrogen atom, a(C1-C4) alkyl group, a(C1-C4) alkoxy group or a fluorine atom; said compounds being in the state of a base or an addition salt to an acid. The invention can be used in therapeutics.
Robic
Sanofi-Aventis
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