Method for predicting susceptibility to radiation pneumonitis

Details Method for predicting susceptibility to radiation pneumonitis Method for predicting susceptibility to radiation pneumonitis

C - Chemistry, Metallurgy

12

Q

C12Q 1/28 (2006.01) C12Q 1/26 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2653977

Provided is a method for determining whether an individual is likely to be susceptible to radiation pneumonitis from radiation therapy and for developing a treatment based on the determination of susceptibility. The method involves measuring SOD and GPX activity levels. A high SOD or low GPX activity, or a combination thereof, is indicative that the individual is likely to be susceptible to radiation pneumonitis.

La présente invention concerne un procédé permettant de déterminer si un individu court le risque de développer une sensibilité à une pneumonite à la suite de radiations thérapeutiques et de mettre au point un traitement basé sur la détermination de la sensibilité. Le procédé implique une mesure des niveaux d'activité SOD et GPX. Une forte activité SOD ou une faible activité GPX, ou une combinaison des deux, est indicative du risque que court l'individu de développer une sensibilité à une pneumonite résultant d'une irradiation.

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