C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2648459
The present invention relates to aberrant cell signaling by the HIV type I envelope glycoprotein. In particular, the present invention provides compositions and methods for identification of inhibitors of melanocortin receptor pathway stimulation by HIV-I gpl20 and its degradation products. The inhibitors so identified are contemplated to be suitable for treating HIV-related cachexia, T cell hyperactivation and central nervous system disease.
La présente invention concerne la signalisation cellulaire aberrante par la glycoprotéine d'enveloppe du VIH de type I. En particulier, la présente invention concerne des compositions et des procédés permettant d'identifier des inhibiteurs de la stimulation du système de récepteurs de la mélanocortine par la gp120 du VIH-I et de ses produits de dégradation. Les inhibiteurs ainsi identifiés sont considérés comme appropriés pour traiter la cachexie liée au SIDA, l'hyperactivation des lymphocytes T et la maladie du système nerveux central.
Gowling Lafleur Henderson Llp
The Regents Of The University Of California
LandOfFree
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