Rgd-(bacterio)chlorophyll conjugates for photodynamic...

Details Rgd-(bacterio)chlorophyll conjugates for photodynamic... Rgd-(bacterio)chlorophyll conjugates for photodynamic...

A - Human Necessities

61

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A61K 41/00 (2006.01) A61K 49/00 (2006.01) A61K 49/08 (2006.01) A61K 49/14 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2717060

RGD-chlorophyll and RGD-bacteriochlorophyll conjugates that home and accumulate in necrotic tumor domains much longer than in tumor non-necrotic domains are provided for use in minimally invasive tumor-targeted imaging, tumor-targeted photodynamic therapy, and/or on-line prognosis of necrotic tumors.

Cette invention concerne des conjugués RGD-chlorophylle et RGD-bactériochlorophylle qui se logent et saccumulent dans les domaines de tumeurs nécrosantes bien plus longtemps que dans les domaines de tumeurs non nécrosantes ; ces conjugués sont utilisés en imagerie peu invasive à ciblage tumoral, en traitement photodynamique à ciblage tumoral et/ou en pronostic en ligne des tumeurs nécrosantes.

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