Methods of treating multiple sclerosis by administration of...

A - Human Necessities – 61 – K

Patent

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A61K 38/17 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2714335

The present invention relates to methods for treating multiple sclerosis by administering therapeutically effective amounts of an alpha-fetoprotein polypeptide (or a biologically active fragment, derivative, or analog thereof) and an integrin antagonist (e.g., natalizumab) to a patient in need thereof. Also disclosed are compositions and kits that comprise therapeutically effective amounts of an alpha- fetoprotein polypeptide (or a biologically active fragment, derivative, or analog thereof) and an integrin antagonist (e.g., natalizumab).

La présente invention concerne des méthodes destinées au traitement de la sclérose en plaques, comprenant l'administration de doses thérapeutiques d'un polypeptide d'alpha-foetoprotéine (ou d'un fragment, dérivé ou analogue biologiquement actif de celui-ci) et d'un antagoniste de l'intégrine (le natalizumab, par exemple) à un patient nécessitant un traitement de ce type. L'invention concerne également des compositions et des trousses comprenant des doses thérapeutiques d'un polypeptide d'alpha-foetoprotéine (ou d'un fragment, dérivé ou analogue biologiquement actif de celui-ci) et d'un antagoniste de l'intégrine (le natalizumab, par exemple).

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