A method of intraepithelial and systemic exposure of...

Details A method of intraepithelial and systemic exposure of... A method of intraepithelial and systemic exposure of...

A - Human Necessities

61

K

A61K 47/46 (2006.01) A61K 9/00 (2006.01) A61K 47/08 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) A61F 6/06 (2006.01) A61F 13/20 (2006.01)

Patent

CA 2622746

A vaginal or buccal delivery of therapeutic agents having a substrate affinity for metabolic cytochrome P-450 enzymes and membrane efflux transporter systems. A method for augmentation of systemic exposure to the therapeutic agents having a substrate affinity for cytochrome P-450 enzymes and membrane efflux transporter systems, by delivering said agents to the systemic circulation through vaginal or buccal mucosa.

L'invention concerne une délivrance vaginale ou buccale d'agents thérapeutiques ayant une affinité de substrat pour les enzymes P-450 métaboliques, et les systèmes de transport d'écoulements membranaires. L'invention concerne un procédé d'augmentation de l'exposition systémique à des agents thérapeutiques ayant une affinité de substrat aux enzymes P-450 cytochromes et des systèmes d'écoulements membranaires, par délivrance de ces agents à la circulation systémique par les muqueuses vaginales ou buccales.

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