Pharmaceutical compositions with immunosuppresive properties

Details Pharmaceutical compositions with immunosuppresive properties Pharmaceutical compositions with immunosuppresive properties

A - Human Necessities

61

K

A61K 31/66 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2069367

ABSTRACT A new therapeutic use of phospholipid derivatives as immunosuppressants is described, these phospholipid derivatives having a general formula (I): Image (I) wherein A = H; -(CH2)nOH, -(CH2)n-O-CO-R (with n= 1, 2); B = Image , -(CH2)m-O-CO-R (with m= 1,2,3,4) with the limitation that when A = -(CH2)n-O-CO-R, m = 1,2; and Y = serine or inositol, and wherein the R groups may be the same or different, and are radicals of acids that are aliphatic, aromatic, arylaliphatic, alicyclic, or heterocyclic on the condition that at least one R group is the radical of a monounsaturated or polyunsaturated fatty acid, and is preferably chosen from the group consisting of palmitolic acid, oleic acid, linoleic acid, linolenic acid, and arachidonic acid.

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