Non swellable suppository comprising at least one...

Details Non swellable suppository comprising at least one... Non swellable suppository comprising at least one...

A - Human Necessities

61

K

A61K 9/02 (2006.01) A61K 9/00 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2415237

There is provided a suppository comprising at least one biocompatible polymer, wherein the biocompatible polymer is essentially non-biodegradable, and wherein the suppository essentially does not swell when contacted with an aqueous fluid. The suppository may further comprise a plurality of open cells at least partly separated from one another by an interpenetrating matrix comprising at least one biocompatible polymer in branched or crosslinked form. The plurality of interlinked, open cells are capable of containing an aqueous fluid, and the permeability of the suppository ensures that entry of body fluids into the open cells under practical circumstances occurs essentially without dehydration of mucousal membrane tissue contacting the suppository. The suppository futhermore preferably comprises a controlled release formulation.

L'invention concerne un suppositoire comprenant au moins un polymère biocompatible, ledit polymère biocompatible étant sensiblement non-biodégradable et ledit suppositoire ne gonflant pas sensiblement lorsqu'il est mis en contact avec un fluide aqueux. Le suppositoire peut également comprendre une pluralité de cellules ouvertes séparées au moins en partie les unes des autres par l'intermédiaire d'une matrice d'enchevêtrement comprenant au moins un polymère biocompatible ramifié ou réticulé. La pluralité de cellules ouvertes interconnectées peuvent contenir un fluide aqueux et la perméabilité du suppositoire permet d'assurer une entrée de liquides biologiques dans les cellules ouvertes, dans des circonstances pratiques, sans déshydratation du tissu des muqueuses en contact avec le suppositoire. Le suppositoire comprend également de préférence une formulation à libération contrôlée.

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