Toll like receptor modulators

Details Toll like receptor modulators Toll like receptor modulators

C - Chemistry, Metallurgy

12

N

C12N 15/117 (2010.01) A61K 31/7088 (2006.01) A61P 37/02 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) A61K 39/00 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2694973

The invention relates to TLR9 antagonist compounds and their therapeutic or prophylactic use. The invention provides novel immune regulatory oligonucleotides and immunomers as antagonist of TLRs and methods of use thereof. These immune regulatory oligonucleotides have unique sequences that suppress, without completely ablating, TLR-mediated signaling in response to a TLR ligand or TLR signaling agonist. The methods may have use in the prevention and treatment of autoimmunity, inflammation, inflammatory bowel disease, lupus, allergy, asthma, infection, sepsis, cancer and immunodeficiency.

L'invention concerne des composés antagonistes de TLR9 et leur utilisation thérapeutique ou prophylactique. L'invention propose des oligonucléotides régulateurs immunitaires et des immunomères novateurs en tant qu'antagonistes de TLR et des procédés pour leur utilisation. Ces oligonucléotides régulateurs immunitaires ont des séquences géniques qui suppriment, sans pratiquer son ablation complète, la signalisation véhiculée par TLR en réponse à un ligand TLR ou un agoniste de signalisation TLR. Les procédés peuvent avoir une utilisation dans la prévention et le traitement de l'auto-immunité, une inflammation, une affection abdominale inflammatoire, le lupus, une allergie, l'asthme, une infection, une sepsie, un cancer et une immunodéficience.

Affiliated with

Also associated with

Rating

Toll like receptor modulators does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Toll like receptor modulators, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Toll like receptor modulators will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1647081