Optimized nucleotide sequences of vb6-845 for expression of...

Details Optimized nucleotide sequences of vb6-845 for expression of... Optimized nucleotide sequences of vb6-845 for expression of...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/47 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/415 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 9/24 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) C12N 15/29 (2006.01) C12N 15/31 (2006.01) C12N 15/56 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01)

Patent

CA 2684330

An optimized nucleic acid sequence encoding the immunoconjugate VB6-845 is described Modifications to the original VB6-845 include changes in the nucleic acid sequence encoding the VH region, CH region, CL region, VL region, the furm linker and the bouganm toxin. The optimized VB6-845 displays improved recombinant protein expression over the original in an E.coli expression system.

L'invention concerne une séquence d'acide nucléique optimisée codant pour l'immunoconjugué VB6-845. Des modifications apportées à VB6-845 initial comprennent des changements de la séquence d'acide nucléique codant pour la région VH, la région CH, la région CL, la région VL, le liant de la furine et la toxine de la bouganine. Dans un système d'expression d'E.coli, le composant VB6-845 optimisé présente une expression des protéines recombinées meilleure que le VB6-845 initial.

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