C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 38/45 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2264545
The present invention provides a novel human phosphorylase kinase gamma subunit (HPHKG) and the polynucleotide which identifies and encodes HPHKG. The invention provides for expression vectors and host cells comprising the nucleic acid sequence encoding HPHKG. The invention also provides pharmaceutical compositions containing purified HPHKG or antisense molecules to HPHKG for the treatment of diseases associated with expression of HPHKG. The invention also includes diagnostic compositions containing the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding HPHKG or anti- HPHKG antibodies which specifically bind to HPHKG, and the use of such compositions for diagnosis of disease.
La présente invention porte sur une nouvelle sous-unité gamma de la phosphorylase kinase humaine (HPHKG) et sur le polynucléotide identifiant et codant HPHKG. L'invention porte également sur des vecteurs d'expression et des cellules hôtes comprenant la séquence d'acide nucléique codant HPHKG, ainsi que sur des compositions pharmaceutiques contenant HPHKG purifiée ou des molécules antisens contre HPHKG, ces compositions étant destinées au traitement de pathologies associées à l'expression de HPHKG. L'invention porte aussi sur des compositions diagnostiques contenant le polynucléotide, ses fragments ou son complément, qui s'hybride avec la séquence génomique ou le produit de transcription des polynucléotides codant HPHKG ou des anticorps anti-HPHKG qui se lient spécifiquement à HPHKG, et sur l'utilisation de ces compositions dans le diagnostic de pathologies.
Bandman Olga
Goli Surya K.
Incyte Genomics Inc.
Incyte Pharmaceuticals Inc.
Smart & Biggar
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