Treatment of androgen-related diseases

Details Treatment of androgen-related diseases Treatment of androgen-related diseases

A - Human Necessities

61

K

A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61K 31/57 (2006.01) A61K 31/575 (2006.01) A61K 31/58 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2062792

A method of treatment of androgen-related diseases such as prostate cancer in susceptible male animals, including humans, comprises administering novel antiandrogens and novel sex steroid biosynthesis inhibitors as part of a combination therapy. Sex steroid biosynthesis inhibitors, especially those capable of inhibiting conversion of dehydroepiandrosterone (DHEA) or 4- androstenedione (.DELTA.4-dione) to natural sex steroids (and testosterone into dihydrotestosterone) in peripheral tissues, are used in combination with antiandrogens, usually after blockade of testicular hormonal secretions. Antiestrogens can also be part of the combination therapy. Pharmaceutical compositions and two, three, four and five component kits are useful for such combination treatment.

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