Preparation of macromolecular conjugates by four-component...

Details Preparation of macromolecular conjugates by four-component... Preparation of macromolecular conjugates by four-component...

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2568388

Polymer-biomolecule conjugates are prepared, generally in a site-specific or - selective manner, by a four-component condensation reaction. The method may be used to prepare conjugates having two polymer molecules attached at a single site on a biomolecule. The conjugates are typically water soluble and have beneficial pharmacological properties, such as reduced immunogenicity and increased circulation time.

L'invention concerne la préparation de conjugués biomoléculaires polymères, d'ordinaire d'une manière spécifique ou sélective du site, par réaction de condensation à quatre composants. On peut utiliser ce procédé pour préparer des conjugués ayant deux molécules polymères fixées à un site simple sur une biomolécule. Les conjugués sont d'ordinaire hydrosolubles et présentent des propriétés pharmacologiques intéressantes, par exemple une immunogénicité réduite et un temps de circulation accru.

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