Method for assessing pyrimidine metabolism

G - Physics – 01 – N

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G01N 24/00 (2006.01) G01N 33/00 (2006.01)

Patent

CA 2600921

A method is provided for determining pyrimidine metabolism of an individual. By collecting a saliva sample containing a concentration of a pyrimidine from an individual, the saliva sample can be measured for the pyrimidine to yield a pyrimidine measurement. Through the comparison of the pyrimidine measurement to a value measured for a control person with a known pyrimidine metabolism, the relative pyrimidine metabolism of the individual is determined. An individual with a defective or deficient ability to metabolize pyrimidines is vulnerable to dietary excess of pyrimidines or is at a great likelihood of suffering undesirable and potentially lethal side effects if the individual is given anti-cancer or anti-viral pyrimidine analogs. A kit is provided that includes a pipette and a piece of filter paper for collecting saliva from an individual. The use of saliva as a sampling substance indicative of an individual's pyrimidine metabolism affords numerous advantages over conventional usage of blood or urine.

Méthode de détermination du métabolisme de la pyrimidine chez un individu au moyen d'un échantillon de salive. En comparant le taux de pyrimidine dans la salive de l'individu à une valeur relevée dans la salive d'une personne témoin dont le métabolisme de la pyrimidine est connu, on peut déterminer le métabolisme de la pyrimidine chez cet individu. Un individu dont l'aptitude à métaboliser la pyrimidine est défectueuse ou déficiente est vulnérable à des excès pyrimidiques d'ordre alimentaire de pyrimidines ou s'expose fortement à des effets secondaires indésirables, voire mortels si elle absorbe des analogues de la pyrimidine dans le cadre d'un traitement anticancéreux ou anti-viral. Est décrit une trousse avec pipette et papier filtrant pour le prélèvement de la salive. L'utilisation de la salive en tant qu'indicateur du métabolisme de la pyrimidine offre de nombreux avantages sur l'usage traditionnel du sang ou de l'urine.

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