Use of 2-iminobiotin for the prevention or treatment of...

Details Use of 2-iminobiotin for the prevention or treatment of... Use of 2-iminobiotin for the prevention or treatment of...

A - Human Necessities

61

K

A61K 31/4188 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2419302

A selective inhibitor of neuronal nitric oxide synthase (nNOS) and of inducible nitric oxide synthase (iNOS), which does not substantially inhibit endothelial nitric oxide synthase (eNOS), can be effectively used for the treatment, in human or other mammalian neonates, of the effects of complications during childbirth. Such effects include perinatal asphyxia and hypoxia-ischemia. A very useful example of such a selective inhibitor is 2- iminobiotin.

Un inhibiteur sélectif de la synthase d'oxyde nitrique (nNOS) et de la synthase d'oxyde nitrique inductible (iNOS), qui n'inhibe pas sensiblement la synthase d'oxyde nitrique endothéliale (eNOS) peut être utilisé efficacement pour le traitement, chez l'humain ou d'autres nouveau-nés mammaliens, des effets des complications liées à la naissance. Ces effets comprennent l'asphyxie périnatale et l'hypoxie-ischémie. Un exemple très utile de cet inhibiteur sélectif est la 2-iminobiotine.

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