Substituted phenyl sulfonamides as selective .beta.3...

Details Substituted phenyl sulfonamides as selective .beta.3... Substituted phenyl sulfonamides as selective .beta.3...

C - Chemistry, Metallurgy

07

C

C07C 311/00 (2006.01) A61K 31/18 (2006.01) A61K 31/33 (2006.01) C07C 311/13 (2006.01) C07C 311/14 (2006.01) C07C 311/21 (2006.01) C07C 311/29 (2006.01) C07C 311/44 (2006.01) C07C 311/46 (2006.01) C07C 311/47 (2006.01) C07D 209/04 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 209/34 (2006.01) C07D 213/65 (2006.01) C07D 213/71 (2006.01) C07D 213/73 (2006.01) C07D 215/36 (2006.01) C07D 261/20 (2006.01) C07D 277/74 (2006.01) C07D 285/14 (2006.01) C07D 307/79 (2006.01) C07D 307/82 (2006.01) C07D 311

Patent

CA 2114712

TITLE OF THE INVENTION SUBSTITUTED PHENYL SULFONAMIDES AS SELECTIVE .beta.3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY ABSTRACT OF THE INVENTION Substituted phenylsulfonamides are selective .beta.3 adrenergic receptor agonists with very little .beta.1 and .beta.2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduced neurogenic inflammation or as antidepressant agents. The compounds are prepared by coupling an aminoalkylphenyl-sulfonamide with an appropriately substituted alkyl epoxide. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility are also disclosed.

Affiliated with

Also associated with

Rating

Substituted phenyl sulfonamides as selective .beta.3... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted phenyl sulfonamides as selective .beta.3..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted phenyl sulfonamides as selective .beta.3... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1648449