Treatment of viral infections

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/775 (2006.01) A61K 38/10 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2548585

The present invention concerns polypeptides derived from a tandem repeat of apoE141-149 and their uses as medicaments. The peptides may comprise the tandem repeat, and truncations thereof, for which at least one Leucine (L) is replaced by an amino acid with a side chain comprising at least 4 carbon atoms and at least one Nitrogen atom. Such peptides are useful for preventing or treating viral infections.

L'invention concerne des polypeptides dérivés d'une séquence répétée en tandem d'apoE¿141-149? et leurs utilisations en tant que médicaments. Lesdits peptides peuvent comprendre la séquence répétée en tandem, et des troncatures de celle-ci, pour lesquelles au moins une leucine (L) est remplacée par un acide aminé qui possède une chaîne latérale comprenant au moins 4 atomes de carbone et au moins un atome d'azote. Lesdits peptides sont utiles dans la prévention ou le traitement d'infections virales.

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