Metal ion chelators and therapeutic use thereof

Details Metal ion chelators and therapeutic use thereof Metal ion chelators and therapeutic use thereof

C - Chemistry, Metallurgy

07

D

C07D 213/53 (2006.01) A61K 31/444 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2515027

The present invention relates to compounds which are capable of chelating metal ions. In particular, the present invention relates to (thio)semicarbazone compounds and (thio)hydrazone compounds which are capable of chelating metal ions, including iron ions. Also disclosed are therapeutic use of such compounds and/or their metal ion complexes, including methods of treating diseases associated with cell proliferation.

L'invention concerne des composés aptes à la chélation d'ions métalliques et, en particulier, des composés de (thio)semicarbazone et des composés de (thio)hydrazone aptes à la chélation d'ions métalliques, y compris les ions de fer. La présente invention porte également sur l'utilisation thérapeutique de tels composés et/ou de leurs complexes d'ions métalliques, ainsi que sur des méthodes pour traiter des maladies associées à la prolifération cellulaire.

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