A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/12 (2006.01) A61K 31/7036 (2006.01) A61K 31/7052 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2754604
Oral drug delivery formulations which specifically administer antibacterial agents to the ileum, caecum, and/or the colon, without significant administration elsewhere in the gastrointestinal tract, are disclosed. The formulations include, as actives, a combination of a macrolide or aminoglysoside, or quinolone antibacterial and an anti-Gram-negative lipopeptide (polymyxin) antibacterial agent or other peptide antibacterials effective against Gram- negative bacteria. The formulations can be used to treat infections or unwanted colonization in the colon, and to provide effective decontamination of the colonic flora from unwanted or potentially pathogenic bacteria.
L'invention porte sur des formulations d'administration de médicaments orale qui administrent de façon spécifique des agents antibactériens à l'iléum, au caecum et/ou au côlon, sans administration significative en un autre endroit du tractus gastro-intestinal. Les formulations comprennent, en tant qu'éléments actifs, une combinaison d'un macrolide ou d'un aminoglysoside, ou d'un quinolone antibactérien et/ou d'un agent antibactérien de lipopeptide anti-gram négatif (polymyxine) ou autre antibactérien peptidique efficace contre les bactéries gram négatives. Les formulations peuvent être utilisées pour traiter des infections ou une colonisation indésirable dans le côlon, et pour fournir une décontamination efficace de la flore du côlon des bactéries indésirables ou potentiellement pathogènes.
Andremont Antoine
de Gunzburg Jean
Lescure Francois
Assistance Publique-Hopitaux de Paris
Da Volterra
Robic
Universite Paris Diderot ( Paris 7)
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