Oligoribonucleotides and uses thereof

Details Oligoribonucleotides and uses thereof Oligoribonucleotides and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) C07H 21/02 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 31/12 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2667297

The invention relates to immunostimulatory RNA oligonucleotides (ORN). In particular the ORN have an immunostimulatory ORN motif directly or indirectly flanked by a 3' poly G motif and optionally a 5' poly-G motif. The invention also relates to methods including therapeutic methods and screening methods and related kits for use of the ORN.

La présente invention concerne des oligonucléotides d'ARN immunostimulants (ORN). En particulier, les ORN comprennent un motif ORN immunostimulant flanqué directement ou indirectement par un motif poly G 3' et éventuellement un motif poly G 5'. L'invention concerne également des procédés comprenant des procédés thérapeutiques et des procédés de criblage ainsi que des trousses associées pour l'utilisation des ORN.

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