Prediction of functional and structural properties of...

G - Physics – 01 – N

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G01N 33/68 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2433387

The invention provides a method for identifying a polypeptide that binds a ligand. The method includes the steps of (a) comparing a sequence of a polypeptide to a sequence model for polypeptides that bind a ligand, wherein the sequence model comprises representations of amino acids consisting of a subset of amino acids, the subset of amino acids having one or more atom within a selected distance from a bound ligand in the polypeptides that bind the ligand; and (b) determining a relationship between the sequence and the sequence model, wherein a correspondence between the sequence and the sequence model identifies the polypeptide as a polypeptide that binds the ligand.

L'invention concerne une méthode pour identifier un polypeptide qui se lie à un ligand. Ce procédé comprend les étapes suivantes : (a) comparer une séquence d'un polypeptide à un modèle de séquences pour des polypeptides qui se lient à un ligand, le modèle de séquence comprenant des représentations d'acides aminés constitués d'un sous-ensemble d'acides aminés qui présente au moins un atome à une distance sélectionnée d'un ligand lié dans les polypeptides qui se lient au ligand ; et (b) déterminer un lien entre la séquence et le modèle de séquence, une correspondance entre la séquence et le modèle de séquence identifiant le polypeptide comme étant un polypeptide se liant au ligand.

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