Use of sibutramine analogues to lower lipid levels

Details Use of sibutramine analogues to lower lipid levels Use of sibutramine analogues to lower lipid levels

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 31/137 (2006.01)

Patent

CA 2266378

A compound of formula (I) or a pharmaceutically acceptable salt thereof in which R1 and R2 are independently H or methyl (for example N,N-dimethyl-1-(1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl amine hydrochloride optionally in the form of its monohydrate) is used for lowering lipid levels and/or increasing the HDL : LDL cholesterol ratio in humans, for example in humans having hyperlipidaemia, hypercholesterolaemia or hypertriglyceridaemia.

L'invention concerne un composé présentant la formule (I) ou un sel pharmaceutiquement acceptable de ce dernier, dans lequel R1 et R2 sont indépendamment H ou méthyle (par exemple, de l'hydrochlorure d'amine N,N-diméthyle-1-(1-(4-chlorophényle)cyclobutyl)-3-méthylbutyl éventuellement sous la forme de son monohydrate). Ce composé est utilisé pour abaisser le taux de lipides et/ou augmenter le rapport de cholestérol HDL/LDL chez l'homme, par exemple, chez l'homme souffrant d'hyperlipidémie, hypercholestérolémie ou hypertriglycéridémie.

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