Lithium combinations, and uses related thereto

A - Human Necessities – 61 – K

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A61K 33/00 (2006.01)

Patent

CA 2567249

The present invention relates to combinatorial therapies for treating anxiety, depression or psychotic conditions using a lithium salt and a psychoactive drug selected from the group consisting of serotonin reuptake inhibitor, a 5HT2 receptor antagonist, an anticonvulsant, a norepinephrine reuptake inhibitor, an .alpha.-adrenoreceptor antagonist, an NK-3 antagonist, an NK-1 receptor antagonist, a PDE4 inhibitor, an Neuropeptide Y5 Receptor Antagonists, a D4 receptor antagonist, a 5HT1A receptor antagonist, a 5HT1D receptor antagonist, a CRF antagonist, a monoamine oxidase inhibitor, a sedative-hypnotic drug, and an atypical antipsychotic.

L'invention concerne des traitements combinatoires de l'anxiété, de la dépression ou des états psychotiques, au moyen d'un sel de lithium et d'un médicament psychotrope choisi dans le groupe constitué par un inhibiteur du recaptage de la sérotonine, un antagoniste du récepteur 5HT¿2?, un anticonvulsif, un inhibiteur du recaptage de la norépinéphrine, un antagoniste de l'.alpha.-adrénorécepteur, un antagoniste de NK-3, un antagoniste du récepteur NK-1, un inhibiteur de PDE4, des antagonistes du récepteur Y5 des neuropeptides, un antagoniste du récepteur D4, un antagoniste du récepteur 5HT¿1A?, un antagoniste du récepteur 5HT¿1D?, un antagoniste du CRF, un inhibiteur de la monoamine oxydase, un médicament sédatif hypnotique et un antipsychotique atypique.

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