C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/519 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2702447
The invention relates to novel dihydrothienopyrimidines of the formula 1, and to pharmacologically acceptable salts thereof, formula (1) in which X is SO or SO2, but preferably SO, and either R3 is a monosubstituted phenyl ring in the ortho position or in the meta position, or R3 is a phenyl ring bisubstituted in any positions, and pharmaceutical compositions which comprise these compounds. These novel dihydrothienopyrimidines are suitable for the treatment of respiratory or gastrointestinal symptoms or disorders, inflammatory disorders of the joints, of the skin or of the eyes, disorders of the peripheral or central nervous system or cancers.
La présente invention a pour objet de nouvelles dihydrothiénopyrimidines de la Formule 1, ainsi que leurs sels pharmacologiquement acceptables, Formule (1) dans laquelle X représente SO ou bien SO2, de préférence toutefois SO, et R3 représente soit un cycle phényle monosubstitué en position ortho ou en position méta, soit un cycle phényle bisubstitué en des positions quelconques, ainsi que des compositions pharmaceutiques qui contiennent ces composés. Ces nouvelles dihydrothiénopyrimidines sont appropriées au traitement des malaises ou maladies gastro-intestinaux ou des voies respiratoires, des maladies inflammatoires des articulations, de la peau ou des yeux, des maladies du système nerveux central ou périphérique, ou encore des cancers.
Fiegen Dennis
Fox Thomas
Goeggel Rolf
Hoenke Christoph
Klinder Klaus
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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