Inhibition of atherosclerosis by diindolylmethane analogs

Details Inhibition of atherosclerosis by diindolylmethane analogs Inhibition of atherosclerosis by diindolylmethane analogs

A - Human Necessities

61

K

A61K 31/404 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2567377

Diindolylmethane analogs such as 1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes can be used to treat atherosclerosis and other vascular disease states. The analogs have been shown to display antiinflammatory effects in endothelial cells, suggesting their clinical applicability.

L'invention concerne des analogues de di-indolylméthane, notamment des 1,1-bis(3'-indolyl)-1-(p-substitué phényl)méthanes pouvant être utilisés pour traiter l'athérosclérose et d'autres maladies vasculaires. Ces analogues présentent des effets anti-inflammatoires dans des cellules endothéliales, ce qui suggère des possibilités dans des applications cliniques.

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