Sn-38 lipid complexes and methods of use

Details Sn-38 lipid complexes and methods of use Sn-38 lipid complexes and methods of use

A - Human Necessities

61

K

A61K 31/4745 (2006.01) A61K 9/127 (2006.01) A61K 47/06 (2006.01) A61K 47/44 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2427467

The present invention is for novel compositions and methods for treating diseases caused by cellular proliferation, particularly, for treating cancer in mammals and more particularly in humans. The therapeutic compositions of the present invention include SN-38 lipid complexes in which the complexes can contain any of a variety of neutral or charged lipids and, desirably, cardiolipin. The compositions are capable of efficiently incorporating SN-38 into complexes and are capable of solubilizing relatively high concentrations of SN-38.

La présente invention concerne des compositions et des procédés pour traiter des maladies dues à une prolifération cellulaire, en particulier pour traiter le cancer chez les mammifères et plus particulièrement chez les humains. Les compositions thérapeutiques faisant l'objet de la présente invention comprennent des complexes lipidiques à base de SN-38, les complexes pouvant contenir n'importe quel lipide choisi parmi une variété de lipides chargés ou neutres et, de préférence, de la cardiolipine. Ces compositions peuvent incorporer efficacement du SN-38 dans des complexes et solubiliser des concentrations relativement élevées de SN-38.

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