Non-invasive localization of a light-emitting conjugate in a...

A - Human Necessities – 61 – K

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A61K 49/00 (2006.01) A61B 5/00 (2006.01) A61B 5/05 (2006.01) A61K 39/112 (2006.01) C07K 14/195 (2006.01) C12Q 1/02 (2006.01) C12Q 1/66 (2006.01) C12Q 1/68 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2237983

Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.

La présente invention concerne des procédés et des compositions permettant la détection et la localisation de lumière provenant d'un mammifère. L'invention concerne également des procédés permettant de cibler l'émission lumineuse sur des régions sélectionnées, et permettant de faire un suivi d'entités à l'intérieur du mammifère. L'invention concerne en outre des cobayes animaux d'états pathologiques ainsi que des procédés permettant de localiser et de suivre la progression d'une pathologie ou d'un germe pathogène chez l'animal. Ces procédés permettent également de cribler systématiquement des composés thérapeutiques efficaces contre la pathologie ou le germe pathogène.

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