G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 1/30 (2006.01) C12M 1/34 (2006.01) C12M 1/40 (2006.01) G01N 21/79 (2006.01) G01N 27/403 (2006.01) G01N 27/44 (2006.01) G01N 31/16 (2006.01)
Patent
CA 2266930
A small liquid sample (24) to be tested is contained within an annulus (18) on the upper surface (14) of a substrate (12). In one embodiment, a reagent diffuses into the sample through a membrane (28) in a junction hole (26). the junction hole connecting upper (14) and lower (16) surfaces of the substrates. Optical measuring equipment (70, 72) detects a measurable change in an optical property of the sample. In an alternate embodiment, a flow of gas (30) directed at a small liquid sample (24), causes the sample to flow in a controlled manner over the surface of an electrode (20), disposed on the substrate surface (14). In another alternate enbodiment, a spacial averaging electrode (20) is disposed in a non-homogeneous sample (24). Highly reproducible and accurate hydrodynamic electrochemical studies and analyses of microliter size samples are thus achievable, without the need for moving mechanical parts.
Un petit échantillon liquide à tester est contenu dans un espace annulaire (18), à la surface supérieure (14) d'un substrat (12). Un réactif se diffuse dans l'échantillon par une membrane (28) placée dans un orifice de liaison (26), lequel relie les surfaces supérieure (14) et inférieure (16) du substrat. Un appareil de mesure optique (70, 72) détecte une modification mesurable de propriété optique de l'échantillon. On peut aussi diriger un flux de gaz (30) vers un petit échantillon liquide (24), contenu dans un espace annulaire à la surface (14) d'un substrat (12), ce qui crée un flux entraînant l'échantillon de manière régulée sur la surface d'une électrode (20) placée à la surface du substrat (14). On peut aussi placer une électrode (20) à l'intérieur d'un échantillon non homogène (24).
Cserey Andrea
Gratzl Miklos
Hui Kwong Yue
Case Western Reserve University
Sim & Mcburney
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