Polymorphs of the cysteine protease inhibitor...

Details Polymorphs of the cysteine protease inhibitor... Polymorphs of the cysteine protease inhibitor...

C - Chemistry, Metallurgy

07

C

C07C 317/48 (2006.01) A61K 31/277 (2006.01)

Patent

CA 2580219

The present invention is directed to polymorphs of N-(1-cyanocyclopropyl)-3- cyclopropylmethanesulfonyl-2(R)-(2,2,2-trifluoro-1(S)-4- fluorophenylethylamino)-propionamide, methods of using them to treat a disease mediated by cathepsin S, pharmaceutical compositions comprising such polymorphs, and processes for preparing them.

La présente invention a pour objet des formes polymorphes du N-(1-cyanocyclopropyl)-3-cyclopropylméthanesulfonyl-2(R)-(2,2,2-trifluoro-1(S)-4-fluorophényléthylamino)propionamide, ainsi que des méthodes d~utilisation desdites formes pour traiter une maladie induite par la cathepsine S, des préparations pharmaceutiques contenant lesdites formes, et des procédés de synthèse desdites formes.

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