Method for producing dichloromethylpyridines

C - Chemistry – Metallurgy – 07 – D

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C07D 213/61 (2006.01) C07D 213/26 (2006.01) C07D 213/63 (2006.01)

Patent

CA 2085333

ABSTRACT A method for producing a dichloromethylpyridine of the formula (II): Image (II) wherein each of R1, R2, R3 and R4 which are independent of one another, is a hydrogen atom, a halogen atom, an alkoxy group or a phenoxy group which may be substituted, provided that R1, R2, R3 and R4 are not simultaneously hydrogen atoms, which comprises reacting a trichloromethylpyridine of the formula (I): (I) Image wherein R1, R2, R3 and R4 are as defined above, with a reducing agent, wherein: (1) a dialkyl phosphite or a trialkyl phosphite is used as the reducing agent, and the reaction is conducted in the presence of a basic substance and an alcohol solvent, or (2) a trialkyl phosphine or triphenyl phosphine is used as the reducing agent, and the reaction is conducted in the presence of an alcohol solvent.

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