C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/61 (2006.01) C07D 213/26 (2006.01) C07D 213/63 (2006.01)
Patent
CA 2085333
ABSTRACT A method for producing a dichloromethylpyridine of the formula (II): Image (II) wherein each of R1, R2, R3 and R4 which are independent of one another, is a hydrogen atom, a halogen atom, an alkoxy group or a phenoxy group which may be substituted, provided that R1, R2, R3 and R4 are not simultaneously hydrogen atoms, which comprises reacting a trichloromethylpyridine of the formula (I): (I) Image wherein R1, R2, R3 and R4 are as defined above, with a reducing agent, wherein: (1) a dialkyl phosphite or a trialkyl phosphite is used as the reducing agent, and the reaction is conducted in the presence of a basic substance and an alcohol solvent, or (2) a trialkyl phosphine or triphenyl phosphine is used as the reducing agent, and the reaction is conducted in the presence of an alcohol solvent.
Katsuyama Isamu
Nasu Rikuo
Shimura Taku
Ishihara Sangyo Kaisha Ltd.
Smart & Biggar
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