Development of mutations useful for attenuating dengue...

Details Development of mutations useful for attenuating dengue... Development of mutations useful for attenuating dengue...

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/12 (2006.01) A61P 31/14 (2006.01) A61P 37/04 (2006.01) C07K 16/10 (2006.01) C12N 15/00 (2006.01) C12N 15/40 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2755964

This invention provides flavivirus having a viral genome modified by the introduction of one or more mutations. The flavivirus may be attenuated and may have a phenotype that is temperature sensitivity, host-cell restriction or host-cell adaptation for improved replication. A menu of mutations was developed that is useful in fine- tuning attenuation and growth characteristics of dengue virus vaccines.

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