Platelets from stem cells

Details Platelets from stem cells Platelets from stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/078 (2010.01) C12N 5/0735 (2010.01) A61K 35/14 (2006.01) A61P 7/04 (2006.01)

Patent

CA 2586053

Human embryonic stem cells are induced to differentiate first into the hematopoietic lineage and then into megakaryocytes, the cells which generate platelets. The proper in vitroculture of megakaryocytes results in the production and shed of platelets. This makes possible, for the first time, the in vitro production of a human blood factor needed by many patients.

L'invention concerne des cellules souches embryonnaires humaines induites pour se différencier en premier lieu dans la lignée hématopoïétique, puis en mégacaryocytes, les cellules générant des plaquettes. La culture in vitro adaptée des mégacaryocytes permet la production et la perte de plaquettes. Ceci rend possible, pour la première fois, la production in vitro d'un facteur sanguin humain dont ont besoin de nombreux patients.

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