New use

Details New use New use

A - Human Necessities

61

K

A61K 31/437 (2006.01) A61K 31/405 (2006.01) A61K 31/4375 (2006.01) A61K 31/5025 (2006.01) A61K 31/506 (2006.01) A61K 45/00 (2006.01) A61K 45/06 (2006.01) A61P 1/04 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2440100

The present invention relates to a new use of certain pharmaceutically active compounds in the treatment and/or prevention of medicament induced gastric ulcer. More particularly the invention is directed to the use of said compounds, and pharmaceutically acceptable salts thereof, for the treatment and/or prevention of NSAID (non-steroidal antiinflammatory drugs) induced gastric ulcer as well as a pharmaceutical composition in the unit dosage form for the prevention of NSAID induced gastric ulcer in a mammal comprising an NSAID together with a 6-carboxamido-imidazo[1,2-a]pyridine compounds. Other pharmaceutically active compounds used in the present invention comprises COX- 2 inhibitors, NO-NSAIDs and bisphosphonates.

La présente invention concerne une utilisation nouvelle de certains composés pharmaceutiques actifs dans le traitement et/ou la prévention d'ulcère provoqué par des médicaments. Plus particulièrement l'invention concerne l'utilisation desdits composés, et leurs sels pharmaceutiquement acceptables, pour le traitement et/ou la prévention d'ulcère provoqué par les anti-inflammatoires non stéroïdiens (AINS) ainsi qu'une composition pharmaceutique sous la forme de dose unitaire pour la prévention d'ulcère provoqué par les AINS chez un mammifère comportant un AINS avec des composés de 6-carboxamido-imidazo[1,2-a]pyridine. D'autres composés pharmaceutiquement actifs utilisés dans la présente invention comprennent des inhibiteurs de la cyclo-oxygénase-2, des AINS à libération d'oxyde nitrique et des bisphosphonates.

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