Method for reducing immune and hemostatic dysfunctions...

Details Method for reducing immune and hemostatic dysfunctions... Method for reducing immune and hemostatic dysfunctions...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61M 1/36 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2186108

The use of anti-C5 antibodies to reduce the dysfunction of the immune and hemostatic systems associated with extracorporeal circulation procedures, such as, cardiopulmonary bypass procedures, is disclosed. The antibodies have been found to significantly reduce complement activation, platelet activation, leukocyte activation, and platelet-leukocyte adhesion associated with such procedures.

On utilise des anticorps anti-C5 pour réduire le dysfonctionnement des systèmes immunitaire et hémostatique associés aux procédures de circulation extra-corporelle telles que les procédures de dérivation cardio-pulmonaire. On a découvert que ces anticorps réduisent de façon appréciable l'activation du système complémentaire, l'activation des plaquettes, l'activation des leucocytes et l'adhésion des plaquettes et des leucocytes associées à ces procédures.

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