Compositions and methods for protein deaggregation

Details Compositions and methods for protein deaggregation Compositions and methods for protein deaggregation

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2614082

Compositions and methods are provided for achieving the deaggregation of binding proteins including, but not limited to, protein ligands, soluble receptors, antibodies, antibody fragments, variable fragment single-chain antibodies (scFv), and small modular immunopharmaceutical products (SMIP~ products). The compositions, which are suitable for the deaggregation of highly concentrated solutions of binding proteins, contain one or more chaotrope, are typically formulated at an acidic pH, and may be used to provide binding proteins suitable for the preparation of pharmaceutical compositions and administration in vivo to a patient.

La présente invention concerne des compositions et des méthodes qui sont utilisées pour effectuer la désagrégation des protéines de liaison telles que, sans limitation, les ligands protéiques, les récepteurs solubles, les anticorps, les fragments d'anticorps, les anticorps monocaténaires à fragment variable (scFv) et les produits immunopharmaceutiques modulaires de petite taille (produits SMIPR). Les compositions, qui sont appropriées à la désagrégation de solutions hautement concentrées de protéines de liaison contiennent au moins un chaotrope, sont spécifiquement formulées à un pH acide et peuvent être utilisées pour produire des protéines de liaison adaptées à la préparation de compositions pharmaceutiques et à l'administration in vivo à un patient.

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