Identification of novel ige epitopes

Details Identification of novel ige epitopes Identification of novel ige epitopes

C - Chemistry, Metallurgy

07

K

C07K 7/00 (2006.01) A61K 39/00 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2552999

The present invention relates to novel peptide epitopes derived from the CH3 domain of IgE which are recognized by high affinity antibodies that specifically bind IgE. These novel peptides may be used for both active immunization of a subject by administering these peptides to generate high affinity antibodies in a subject, as well as for generating high affinity anti- IgE antibodies in non-human hosts that specifically bind to these regions of IgE for passive immunization of a subject.

L'invention se rapporte à de nouveaux épitopes peptidiques issus du domaine CH3 d'IgE qui sont identifiés par des anticorps à affinité élevée qui se lient spécifiquement à IgE. Ces nouveaux peptides peuvent servir aussi bien pour l'immunisation active d'un sujet par administration de ces peptides afin de générer des anticorps à affinité élevée chez un sujet, que pour la génération d'anticorps anti-IgE à affinité élevée chez des hôtes non-humains qui se lient spécifiquement à ces zones d'IgE en vue de l'immunisation passive d'un sujet.

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