C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) A61K 31/7052 (2006.01) A61K 38/00 (2006.01) A61K 38/48 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 31/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12N 15/57 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2415751
The present invention relates to substantially pure mannin-binding lectin associated serine protease-2 (MASP-2) polypeptides and fragments thereof as well as nucleic acids encoding such polpeptides. Futhermone, the present invention realates to uses of a substantially pure polypeptide comprising amino acid sequences derived from mannan-binding lectin associated serine protease-2 (MASP2) or a functional homologue thereof for the production of a pharmaceutical composition as well as pharmaceutical compositons comprising MASP-2 and/or MASP-2 fragments. In addition the present invetion relates to inhibitors of MASP-2 and pharmaceutical compositiosn compring such inhibitors. Methods for detecting MASP-2 nucleic acid expression are included in the invention.
L'invention concerne des polypeptides sensiblement purs de sérine-protéase-2 associée à la lectine liant le mannose (MASP-2) et leurs fragments ainsi que des acides nucléiques codant pour ces polypeptides. L'invention concerne également les utilisations d'un polypeptide sensiblement pur comprenant des séquences d'acides aminés dérivés de la sérine-protéase-2 associée à la lectine liant le mannose (MASP-2) ou un homologue fonctionnel dudit polypeptide pour la production d'une composition pharmaceutique ainsi que des compostions pharmaceutiques comprenant MASP-2 et/ou des fragments de MASP-2. En outre, l'invention concerne des inhibiteurs de MASP-2 et des compositions pharmaceutiques comprenant ces inhibiteurs. L'invention concerne enfin des méthodes permettant de détecter l'expression d'acides nucléiques de MASP-2.
Jensenius Jens Christian
Thiel Steffen
Deeth Williams Wall Llp
Helion Biotech Aps
Jensenius Jens Christian
Thiel Steffen
LandOfFree
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