Manipulation and detection of protein phosphatase 2c -...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/55 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/40 (2006.01) C12N 9/14 (2006.01) C12N 15/11 (2006.01) C12Q 1/42 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2227306

A method of detecting cancer in a patient by detecting alteration of activity of the gene coding for human type protein phosphatase 2C (PP2C.alpha. and PP2C.beta.) and genetic polymorphisms thereof in a specimen isolated from the patient is disclosed. The invention further provides a method of treating cancer including the steps of first determining the type of cancer and cells expressing the cancer and then preparing a vector which will specifically target the cancer cells and can include regulatory elements to control the expressibility of PP2C.alpha.. The vector is then administered to the patient. Alternatively an antisense vector can be prepared.

L'invention concerne un procédé de détection du cancer chez un patient au moyen de la détection d'une modification d'activité du gène codant pour la protéine phosphatase 2C de type humain (PP2C.alpha. et PP2C.beta.) et pour ses polymorphismes génétiques dans un spécimen isolé depuis le patient. Elle concerne également un procédé de traitement du cancer consistant à déterminer d'abord le type du cancer, ainsi que les cellules exprimant ce cancer, puis à préparer un vecteur qui ciblera de façon spécifique les cellules du cancer et peut comprendre des éléments régulateurs de l'expression de PP2C.alpha.. On administre ensuite ce vecteur au patient. Dans un autre mode de réalisation, on peut préparer un vecteur antisens.

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