Mammalian rad1 genes, polypeptides and methods of use

Details Mammalian rad1 genes, polypeptides and methods of use Mammalian rad1 genes, polypeptides and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C07K 14/435 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 9/22 (2006.01) C12N 15/70 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2268457

The present invention provides isolated nucleic acid molecules encoding mammalian RAD1p polypeptides (such as human and marine RAD1p polypeptides) and allelic variants, mutants, fragments or derivatives thereof. The invention also provides mammalian RAD1p polypeptides encoded by such isolated nucleic acid molecules, antibodies binding to such polypeptides, genetic constructs comprising such nucleic acid molecules, prokaryotic or eukaryotic host cells comprising such genetic constructs, and methods and compositions for use in diagnosing and treating disorders characterized by, or utilizing, a loss of cell cycle checkpoint control or by increased sensitivity to DNA-damaging agents.

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