Process for the purification of gabapentin

Details Process for the purification of gabapentin Process for the purification of gabapentin

C - Chemistry, Metallurgy

07

C

C07C 227/40 (2006.01) C07C 229/28 (2006.01)

Patent

CA 2528315

A process for the preparation of gabapentin which comprises the passage of a gabapentin inorganic salt through a strong cationic ionic exchange resin, the elution of gabapentin fixed on the column, the concentration of the resultant solution and the cristallization from organic solvent, characterized in that the elution of gabapentin fixed on the column is carried out by using an ammonia and alkaline hydroxide aqueous solution, is described.

L'invention concerne une méthode de préparation de la gabapentine, qui consiste à: faire passer un sel inorganique de la gabapentine à travers une forte résine d'échange cationique ionique; éluer la gabapentine fixée sur la colonne; concentrer la solution résultante et effectuer une cristallisation à partir d'un solvant organique. La méthode se caractérise en ce que l'élution de la gabapentine fixée sur la colonne est accomplie avec une solution aqueuse d'ammoniac et d'hydroxide alcalin.

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