A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/195 (2006.01) A61K 31/35 (2006.01) A61M 1/28 (2006.01) A61P 13/00 (2006.01)
Patent
CA 2599252
The protective effect on peritoneum of L-carnitine and its lower alkanoyl derivatives, both in the form of inner or pharmaceutically acceptable salts is disclosed. Concentrations of carnitine from about 0.02 to 0.5% w/v are suitable for preparing a solution for peritoneal dialysis having higher biocompatibility and protecting peritoneum from toxic effects of continuous use of solutions for peritoneal dialysis, in particular ones containing glucose as osmotic agent. A particularly preferred embodiment is a solution for peritoneal dialysis containing carnitine, glucose and xylitol.
L~invention concerne l~effet protecteur sur le péritoine de la L-carnitine et de ses dérivés alkanoyles inférieurs, aussi bien sous forme de sels internes que de sels pharmaceutiquement acceptables. On peut utiliser des concentration de carnitine allant d~environ 0,02 à 0,5% m/v afin de préparer une solution de dialyse péritonéale ayant une biocompatibilité plus élevée et protégeant le péritoine des effets toxiques dus à l~utilisation en continu de solutions de dialyse péritonéale, notamment celles contenant du glucose comme agent osmotique. Dans un mode de réalisation particulièrement préféré de l~invention, la solution de dialyse péritonéale contient de la carnitine, du glucose et du xylitol.
Fetherstonhaugh & Co.
Sigma-Tau Industrie Farmaceutiche Riunite S.p.a.
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