C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/517 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2556413
The invention pertains to substituted quinazoline and isoquinoline compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE-10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.
L'invention concerne des composés de quinazoline et d'isoquinoline substitués qui servent d'inhibiteurs efficaces de la phosphodiestérase (PDE). Plus particulièrement, l'invention concerne des composés qui sont des inhibiteurs sélectifs de la PDE-10. Par ailleurs, l'invention concerne des intermédiaires utilisés dans la préparation desdits composés; des compositions pharmaceutiques qui contiennent lesdits composés; ainsi que l'utilisation de ces composés dans un procédé de traitement de certains troubles du système nerveux central (SNC), ou autres troubles.
Allen Martin Patrick
Chappie Thomas Allen
Humphrey John Michael
Liras Spiros
Whalen William Michael
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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