Antibody specificity transfer using minimal essential...

Details Antibody specificity transfer using minimal essential... Antibody specificity transfer using minimal essential...

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) C07K 16/00 (2006.01) C12N 15/09 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) C40B 30/04 (2006.01) C40B 40/08 (2006.01) C40B 40/10 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2553692

The present invention provides methods of making antibodies having the binding specificity of a reference antibody. Antibodies generated by the methods of the inventions have at least one minimal essential binding specificity determinant from a heavy chain or light chain CDR3 from the reference antibody. The method can be used, e.g., in humanization procedures. The invention also provides libraries and antibodies made in accordance with the methods.

L'invention concerne des procédés permettant de produire des anticorps présentant la spécificité de liaison d'un anticorps de référence. Les anticorps ainsi produits possèdent au moins un déterminant de spécificité de liaison essentielle minimale d'une chaîne lourde ou légère CDR3 de l'anticorps de référence. Le procédé peut être utilisé, par exemple dans des procédures d'humanisation. L'invention concerne également des bibliothèques et des anticorps élaborés conformément à ces procédés.

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