Soluble il-17rcx4 and methods of using in inflammation

Details Soluble il-17rcx4 and methods of using in inflammation Soluble il-17rcx4 and methods of using in inflammation

C - Chemistry, Metallurgy

07

K

C07K 14/15 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2638819

The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL- 17F, IL- 17 A, or both IL- 17A and IL- 17F polypeptide molecules. IL-17A and IL- 17F are cytokines that are involved in inflammatory processes and human disease. IL-17RC is a common receptor for IL- 17A and IL- 17F. The present invention includes methods of using a soluble IL- 17RC receptor, IL- 17RCx4 for treating inflammation.

La présente invention concerne le blocage, l'inhibition, la réduction, l'antagonisme ou la neutralisation de l'activité de molécules polypeptidiques IL-17F, IL-17A ou à la fois IL-17A et IL-17F. Les IL-17A et IL-17F sont des cytokines qui sont impliquées dans les processus inflammatoires et dans des maladies humaines. IL-17RC est un récepteur ordinaire des IL-17A et IL-17F. La présente invention concerne des procédés d'utilisation d'un récepteur IL-17RC soluble, le IL-17RCx4, pour traiter l'inflammation.

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