Substituted 5-(2,2-difluoro-1,3-benzodioxol-5-yl)...

Details Substituted 5-(2,2-difluoro-1,3-benzodioxol-5-yl)... Substituted 5-(2,2-difluoro-1,3-benzodioxol-5-yl)...

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2318184

The present invention relates to a cyclopentenopyridine derivative represented by general formula [I] or a pharmaceutically acceptable salt thereof: (see formula I) wherein Ar is a phenyl group or the like, R1 is a mono- or di-C1-C6 alkylamino group or the like, and R2 is a hydroxyl group or the like, a process for its production and its use as endothelin antagonist.

L'invention concerne un dérivé de cyclopenténopyridine représenté par la formule générale (I) ou un sel pharmaceutiquement acceptable de ce dérivé. Dans ladite formule, Ar est un groupe phényle ou analogue, R<1> est un groupe alkylamino mono- ou di-C1-C6 ou analogue, et R<2> est un groupe hydroxyle ou analogue. L'invention concerne également un procédé relatif à l'élaboration de ce produit.

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