Substituted n-oxide pyrazine derivatives

Details Substituted n-oxide pyrazine derivatives Substituted n-oxide pyrazine derivatives

C - Chemistry, Metallurgy

07

D

C07D 241/52 (2006.01) A61K 31/497 (2006.01) A61P 25/28 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2728680

A N-oxide pyrazine derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: (I) wherein: R1 represents a 4-pyridine ring, a halogen atom; R2 represents a hydrogen atom; R3 represents a hydrogen atom; R4 represents: a phenylCi-3alkyl group, this group being optionally substituted; R5 represents a hydrogen atom; in the form of a free base or of an addition salt with an acid. Use in Therapy

Linvention concerne un dérivé N-oxyde de pyrazine représenté par la formule (I) ou un de ses sels, ou un de ses solvates, ou un de ses hydrates : (I) dans laquelle : R1 représente un cycle 4-pyridine, un atome dhalogène; R2 représente un atome dhydrogène; R3 représente un atome dhydrogène; R4 représente un groupe phényl-alkyle en C1-3, ce groupe étant éventuellement substitué; R5 représente un atome dhydrogène; sous la forme dune base libre ou dun sel daddition avec un acide. Linvention concerne également une utilisation en thérapie.

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