Purified forms of dnase

Details Purified forms of dnase Purified forms of dnase

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) A61K 38/46 (2006.01) C12N 9/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2137237

The present invention provides the identification and characterization of two components of a recombinant preparation of DNase. These components are the purified deamidated and non-deamidated human DNases. Taught herein are the separation of these components and the use of the non-deamidated species as a pharmaceutical per se, and in particular in compositions wherein the species is disclosed within a plastic vial, for use in administering to patients suffering from pulmonary distress.

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